Publications

• Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis.

  Yong Y, Cakir I, Lining Pan P, Biddinger JE, Bluett RJ, Mackie K, Bingham N, Patel S, Ghamari-Langroudi M

  Proc Natl Acad Sci U S A. 2021 Oct; 118(42):

  https://doi.org/10.1073/pnas.2015990118

  PMID: 34654741

• Cocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism.

  Manz KM, Coleman BC, Jameson AN, Ghose DG, Patel S, Grueter BA

  Neuropsychopharmacology. 2022 Feb; 47(3): 652-663.

  https://doi.org/10.1038/s41386-021-01167-3

  PMID: 34545194

• CaMKII Modulates Diacylglycerol Lipase-α Activity in the Rat Nucleus Accumbens after Incubation of Cocaine Craving.

  Murray CH, Gaulden AD, Kawa AB, Milovanovic M, Caccamise AJ, Funke JR, Patel S, Wolf ME

  eNeuro. 2021 Sep; 8(5):

  https://doi.org/10.1523/ENEURO.0220-21.2021

  PMID: 34544759

• In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity.

  Farrell JS, Colangeli R, Dong A, George AG, Addo-Osafo K, Kingsley PJ, Morena M, Wolff MD, Dudok B, He K, Patrick TA, Sharkey KA, Patel S, Marnett LJ, Hill MN, Li Y, Teskey GC, Soltesz I

  Neuron. 2021 Aug; 109(15): 2398-2403.e4.

  https://doi.org/10.1016/j.neuron.2021.05.026

  PMID: 34352214

• Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models.

  Winters ND, Bedse G, Astafyev AA, Patrick TA, Altemus M, Morgan AJ, Mukerjee S, Johnson KD, Mahajan VR, Uddin MJ, Kingsley PJ, Centanni SW, Siciliano CA, Samuels DC, Marnett LJ, Winder DG, Patel S

  J Clin Invest. 2021 Jul;

  https://doi.org/10.1172/JCI146861

  PMID: 34292886

• The endocannabinoid system in humans: significant associations between anandamide, brain function during reward feedback and a personality measure of reward dependence.

  Redlich C, Dlugos A, Hill MN, Patel S, Korn D, Enneking V, Foerster K, Arolt V, Domschke K, Dannlowski U, Redlich R

  Neuropsychopharmacology. 2021 Apr; 46(5): 1020-1027.

  https://doi.org/10.1038/s41386-020-00870-x

  PMID: 33007775

• Cannabis use and posttraumatic stress disorder comorbidity: Epidemiology, biology and the potential for novel treatment approaches.

  Kondev V, Winters N, Patel S

  Int Rev Neurobiol. 2021; 157: 143-193.

  https://doi.org/10.1016/bs.irn.2020.09.007

  PMID: 33648669

• "Corting" stress: post-stress corticosterone administration prevents delayed-onset biobehavioral consequences.

  Yasmin F, Patel S

  Neuropsychopharmacology. 2020 Dec; 45(13): 2135-2136.

  https://doi.org/10.1038/s41386-020-00796-4

  PMID: 32782348

• Cyclooxygenase-2 inhibition prevents stress induced amygdala activation and anxiety-like behavior.

  Morgan A, Gaulden A, Altemus M, Williford K, Centanni S, Winder D, Patel S

  Brain Behav Immun. 2020 Oct; 89: 513-517.

  https://doi.org/10.1016/j.bbi.2020.07.046

  PMID: 32763310

• 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics.

  Bedse G, Hill MN, Patel S

  Biol Psychiatry. 2020 Oct; 88(7): 520-530.

  https://doi.org/10.1016/j.biopsych.2020.01.015

  PMID: 32197779

• α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference.

  Perez RE, Basu A, Nabit BP, Harris NA, Folkes OM, Patel S, Gilsbach R, Hein L, Winder DG

  Neuropsychopharmacology. 2020 Aug; 45(9): 1473-1481.

  https://doi.org/10.1038/s41386-020-0641-z

  PMID: 32074627

• Arrested Development: A Story of How Perinatal Cannabinoids Affect the Maturation of the Prefrontal Cortex.

  Winters ND, Patel S

  Biol Psychiatry. 2020 Apr; 87(7): 595-596.

  https://doi.org/10.1016/j.biopsych.2019.12.011

  PMID: 32164915

• An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability.

  Folkes OM, Báldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, Ayers JK, Baechle JJ, Misra MP, Altemus M, Grueter CA, Grueter BA, Patel S

  J Clin Invest. 2020 Apr; 130(4): 1728-1742.

  https://doi.org/10.1172/JCI131752

  PMID: 31874107

• Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening.

  Marcus DJ, Bedse G, Gaulden AD, Ryan JD, Kondev V, Winters ND, Rosas-Vidal LE, Altemus M, Mackie K, Lee FS, Delpire E, Patel S

  Neuron. 2020 Mar; 105(6): 1062-1076.e6.

  https://doi.org/10.1016/j.neuron.2019.12.024

  PMID: 31948734

• Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states.

  Hartley ND, Gaulden AD, Báldi R, Winters ND, Salimando GJ, Rosas-Vidal LE, Jameson A, Winder DG, Patel S

  Nat Neurosci. 2019 Dec; 22(12): 2000-2012.

  https://doi.org/10.1038/s41593-019-0528-7

  PMID: 31712775

• Cyclooxygenase-2 inhibition reduces anxiety-like behavior and normalizes enhanced amygdala glutamatergic transmission following chronic oral corticosterone treatment.

  Morgan A, Kondev V, Bedse G, Baldi R, Marcus D, Patel S

  Neurobiol Stress. 2019 Nov; 11: 100190-.

  https://doi.org/10.1016/j.ynstr.2019.100190

  PMID: 31467944 ISSN: 2352-2895

• Driving the Downward Spiral: Alcohol-Induced Dysregulation of Extended Amygdala Circuits and Negative Affect.

  Centanni SW, Bedse G, Patel S, Winder DG

  Alcohol Clin Exp Res. 2019 Oct; 43(10): 2000-2013.

  https://doi.org/10.1111/acer.14178

  PMID: 31403699

• Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion.

  Nakamura Y, Dryanovski DI, Kimura Y, Jackson SN, Woods AS, Yasui Y, Tsai S-Y, Patel S, Covey DP, Su T-P, Lupica CR

  Elife. 2019 Oct; 8:

  https://doi.org/10.7554/eLife.47209

  PMID: 31596232

• Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder.

  Bedse G, Centanni SW, Winder DG, Patel S

  Alcohol Clin Exp Res. 2019 Oct; 43(10): 2014-2027.

  https://doi.org/10.1111/acer.14159

  PMID: 31373708

• Leptin Receptor Signaling in Sim1-Expressing Neurons Regulates Body Temperature and Adaptive Thermogenesis.

  Cakir I, Diaz-Martinez M, Lining Pan P, Welch EB, Patel S, Ghamari-Langroudi M

  Endocrinology. 2019 Apr; 160(4): 863-879.

  https://doi.org/10.1210/en.2019-00062

  PMID: 30802281

• The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids.

  Bruehl S, Burns JW, Morgan A, Koltyn K, Gupta R, Buvanendran A, Edwards D, Chont M, Kingsley PJ, Marnett L, Stone A, Patel S

  Pain. 2019 Mar; 160(3): 676-687.

  https://doi.org/10.1097/j.pain.0000000000001447

  PMID: 30562268

• Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence.

  Centanni SW, Morris BD, Luchsinger JR, Bedse G, Fetterly TL, Patel S, Winder DG

  Neuropsychopharmacology. 2019 Feb; 44(3): 526-537.

  https://doi.org/10.1038/s41386-018-0257-8

  PMID: 30390064

• Aspects of Prostaglandin Glycerol Ester Biology.

  Kingsley PJ, Rouzer CA, Morgan AJ, Patel S, Marnett LJ

  Adv Exp Med Biol. 2019; 1161: 77-88.

  https://doi.org/10.1007/978-3-030-21735-8_8

  PMID: 31562623 ISSN: 0065-2598

• Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.

  Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ

  Biol Psychiatry. 2018 Aug; 84(4): 304-315.

  https://doi.org/10.1016/j.biopsych.2017.11.036

  PMID: 29458998

• Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain.

  Morgan AJ, Kingsley PJ, Mitchener MM, Altemus M, Patrick TA, Gaulden AD, Marnett LJ, Patel S

  ACS Chem Neurosci. 2018 Jul; 9(7): 1552-1559.

  https://doi.org/10.1021/acschemneuro.7b00499

  PMID: 29722963

• Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain.

  Wenzel JM, Oleson EB, Gove WN, Cole AB, Gyawali U, Dantrassy HM, Bluett RJ, Dryanovski DI, Stuber GD, Deisseroth K, Mathur BN, Patel S, Lupica CR, Cheer JF

  Curr Biol. 2018 May; 28(9): 1392-1404.e5.

  https://doi.org/10.1016/j.cub.2018.03.037

  PMID: 29681476

• Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.

  Bedse G, Bluett RJ, Patrick TA, Romness NK, Gaulden AD, Kingsley PJ, Plath N, Marnett LJ, Patel S

  Transl Psychiatry. 2018 Apr; 8(1): 92-.

  https://doi.org/10.1038/s41398-018-0141-7

  PMID: 29695817

• Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder.

  Hill MN, Campolongo P, Yehuda R, Patel S

  Neuropsychopharmacology. 2018 Jan; 43(1): 80-102.

  https://doi.org/10.1038/npp.2017.162

  PMID: 28745306

• Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice.

  Cavener VS, Gaulden A, Pennipede D, Jagasia P, Uddin J, Marnett LJ, Patel S

  Front Neurosci. 2018; 12: 479-.

  https://doi.org/10.3389/fnins.2018.00479

  PMID: 30108473 ISSN: 1662-4548

• Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.

  Bedse G, Hartley ND, Neale E, Gaulden AD, Patrick TA, Kingsley PJ, Uddin MJ, Plath N, Marnett LJ, Patel S

  Biol Psychiatry. 2017 Oct; 82(7): 488-499.

  https://doi.org/10.1016/j.biopsych.2017.03.002

  PMID: 28438413

• Cannabis for Pain and Posttraumatic Stress Disorder: More Consensus Than Controversy or Vice Versa?

  Patel S

  Ann Intern Med. 2017 Sep; 167(5): 355-356.

  https://doi.org/10.7326/M17-1713

  PMID: 28806789

• What We Do (and Don't) Know About the Health Effects of Cannabis and Whether Marijuana Is Medicine.

  Patel S, Williams JW, Wallace RB

  Ann Intern Med. 2017 May; 166(10): 747-748.

  https://doi.org/10.7326/M17-0501

  PMID: 28384665

• The endocannabinoid system as a target for novel anxiolytic drugs.

  Patel S, Hill MN, Cheer JF, Wotjak CT, Holmes A

  Neurosci Biobehav Rev. 2017 May; 76(Pt A): 56-66.

  https://doi.org/10.1016/j.neubiorev.2016.12.033

  PMID: 28434588

• Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

  Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S

  Nat Commun. 2017 Mar; 8: 14782-.

  https://doi.org/10.1038/ncomms14782

  PMID: 28348378

• A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members.

  Piomelli D, Cooper Z, Abrams D, Grant I, Patel S

  Cannabis Cannabinoid Res. 2017; 2(1): 155-159.

  https://doi.org/10.1089/can.2017.29009.dpi

  PMID: 28861515 ISSN: 2578-5125

• Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling.

  Doenni VM, Gray JM, Song CM, Patel S, Hill MN, Pittman QJ

  Brain Behav Immun. 2016 Nov; 58: 237-247.

  https://doi.org/10.1016/j.bbi.2016.07.152

  PMID: 27453335

• Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala.

  Robinson SL, Alexander NJ, Bluett RJ, Patel S, McCool BA

  Neuropharmacology. 2016 Sep; 108: 474-484.

  https://doi.org/10.1016/j.neuropharm.2015.12.005

  PMID: 26707595

• Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.

  Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ

  Neuron. 2016 Sep; 91(6): 1244-1252.

  https://doi.org/10.1016/j.neuron.2016.08.017

  PMID: 27618677

• Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking.

  Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LER, Patel S, Winder DG

  Neuropsychopharmacology. 2016 Jul; 41(8): 2062-2071.

  https://doi.org/10.1038/npp.2016.3

  PMID: 26751284

• The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models.

  Patel S, Shonesy BC, Bluett RJ, Winder DG, Colbran RJ

  Biol Psychiatry. 2016 May; 79(10): e78-e79.

  https://doi.org/10.1016/j.biopsych.2015.04.028

  PMID: 26212898

• Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels.

  Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A

  Transl Psychiatry. 2016 May; 6: e809-.

  https://doi.org/10.1038/tp.2016.86

  PMID: 27187231

• Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids.

  Gunduz-Cinar O, Flynn S, Brockway E, Kaugars K, Baldi R, Ramikie TS, Cinar R, Kunos G, Patel S, Holmes A

  Neuropsychopharmacology. 2016 May; 41(6): 1598-1609.

  https://doi.org/10.1038/npp.2015.318

  PMID: 26514583

• Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.

  Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S

  Elife. 2016 May; 5:

  https://doi.org/10.7554/eLife.14137

  PMID: 27162170

• Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function.

  Gray JM, Wilson CD, Lee TTY, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S, Hill MN

  Psychoneuroendocrinology. 2016 Apr; 66: 151-158.

  https://doi.org/10.1016/j.psyneuen.2016.01.004

  PMID: 26821211

• Electrophysiological Measurement of Cannabinoid-Mediated Synaptic Modulation in Acute Mouse Brain Slices.

  Báldi R, Ghosh D, Grueter BA, Patel S

  Curr Protoc Neurosci. 2016 Apr; 75: 6.29.1-6.29.19.

  https://doi.org/10.1002/cpns.8

  PMID: 27063786

• 2-arachidonoylglycerol signaling impairs short-term fear extinction.

  Hartley ND, Gunduz-Cinar O, Halladay L, Bukalo O, Holmes A, Patel S

  Transl Psychiatry. 2016 Mar; 6: e749-.

  https://doi.org/10.1038/tp.2016.26

  PMID: 26926885

• Neurobiological Interactions Between Stress and the Endocannabinoid System.

  Morena M, Patel S, Bains JS, Hill MN

  Neuropsychopharmacology. 2016 Jan; 41(1): 80-102.

  https://doi.org/10.1038/npp.2015.166

  PMID: 26068727

• Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes.

  Brown JA, Ramikie TS, Schmidt MJ, Báldi R, Garbett K, Everheart MG, Warren LE, Gellért L, Horváth S, Patel S, Mirnics K

  Mol Psychiatry. 2015 Dec; 20(12): 1499-1507.

  https://doi.org/10.1038/mp.2014.192

  PMID: 25623945

• Prefrontal inputs to the amygdala instruct fear extinction memory formation.

  Bukalo O, Pinard CR, Silverstein S, Brehm C, Hartley ND, Whittle N, Colacicco G, Busch E, Patel S, Singewald N, Holmes A

  Sci Adv. 2015 Jul; 1(6):

  https://doi.org/10.1126/sciadv.1500251

  PMID: 26504902 ISSN: 2375-2548

• The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium.

  Shonesy BC, Winder DG, Patel S, Colbran RJ

  Neuropharmacology. 2015 Apr; 91: 57-62.

  https://doi.org/10.1016/j.neuropharm.2014.11.026

  PMID: 25484252

• Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.

  Gray JM, Vecchiarelli HA, Morena M, Lee TTY, Hermanson DJ, Kim AB, McLaughlin RJ, Hassan KI, Kühne C, Wotjak CT, Deussing JM, Patel S, Hill MN

  J Neurosci. 2015 Mar; 35(9): 3879-3892.

  https://doi.org/10.1523/JNEUROSCI.2737-14.2015

  PMID: 25740517

• Neuroscience: a cellular basis for the munchies.

  Patel S, Cone RD

  Nature. 2015 Mar; 519(7541): 38-40.

  https://doi.org/10.1038/nature14206

  PMID: 25707800

• Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation.

  Shonesy BC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S

  Cell Rep. 2014 Dec; 9(5): 1644-1653.

  https://doi.org/10.1016/j.celrep.2014.11.001

  PMID: 25466252

• The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury.

  Tchantchou F, Tucker LB, Fu AH, Bluett RJ, McCabe JT, Patel S, Zhang Y

  Neuropharmacology. 2014 Oct; 85: 427-439.

  https://doi.org/10.1016/j.neuropharm.2014.06.006

  PMID: 24937045

• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.

  Bluett RJ, Gamble-George JC, Hermanson DJ, Hartley ND, Marnett LJ, Patel S

  Transl Psychiatry. 2014 Jul; 4: e408-.

  https://doi.org/10.1038/tp.2014.53

  PMID: 25004388

• Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation.

  Hermanson DJ, Gamble-George JC, Marnett LJ, Patel S

  Trends Pharmacol Sci. 2014 Jul; 35(7): 358-367.

  https://doi.org/10.1016/j.tips.2014.04.006

  PMID: 24845457

• Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.

  Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S

  Neuron. 2014 Mar; 81(5): 1111-1125.

  https://doi.org/10.1016/j.neuron.2014.01.012

  PMID: 24607231

• Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation.

  Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S

  Nat Neurosci. 2013 Sep; 16(9): 1291-1298.

  https://doi.org/10.1038/nn.3480

  PMID: 23912944

• Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice.

  Gamble-George JC, Conger JR, Hartley ND, Gupta P, Sumislawski JJ, Patel S

  Psychopharmacology (Berl). 2013 Aug; 228(3): 401-409.

  https://doi.org/10.1007/s00213-013-3042-8

  PMID: 23483200

• Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.

  Gunduz-Cinar O, MacPherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Godlewski G, Ramikie TS, Gorka AX, Alapafuja SO, Nikas SP, Makriyannis A, Poulton R, Patel S, Hariri AR, Caspi A, Moffitt TE, Kunos G, Holmes A

  Mol Psychiatry. 2013 Jul; 18(7): 813-823.

  https://doi.org/10.1038/mp.2012.72

  PMID: 22688188

• CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.

  Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ

  Nat Neurosci. 2013 Apr; 16(4): 456-463.

  https://doi.org/10.1038/nn.3353

  PMID: 23502535

• Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress.

  Ramikie TS, Patel S

  Neuroscience. 2012 Mar; 204: 38-52.

  https://doi.org/10.1016/j.neuroscience.2011.08.037

  PMID: 21884761

• High times for low-frequency stimulation as endocannabinoids engage in hippocampal long-term depression.

  Patel S

  Neuropsychopharmacology. 2012 Feb; 37(3): 583-585.

  https://doi.org/10.1038/npp.2011.275

  PMID: 22240538

• Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.

  Sumislawski JJ, Ramikie TS, Patel S

  Neuropsychopharmacology. 2011 Dec; 36(13): 2750-2761.

  https://doi.org/10.1038/npp.2011.166

  PMID: 21849983

• An odyssey of fear: Homer stresses new mechanisms.

  Patel S, Winder DG

  Biol Psychiatry. 2010 Dec; 68(11): 980-981.

  https://doi.org/10.1016/j.biopsych.2010.10.005

  PMID: 21075227

• Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.

  Ho W-S, Patel S, Thompson JR, Roberts CJ, Stuhr KL, Hillard CJ

  Br J Pharmacol. 2010 Jun; 160(3): 736-746.

  https://doi.org/10.1111/j.1476-5381.2010.00772.x

  PMID: 20590576

• Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability.

  Mozhui K, Karlsson R-M, Kash TL, Ihne J, Norcross M, Patel S, Farrell MR, Hill EE, Graybeal C, Martin KP, Camp M, Fitzgerald PJ, Ciobanu DC, Sprengel R, Mishina M, Wellman CL, Winder DG, Williams RW, Holmes A

  J Neurosci. 2010 Apr; 30(15): 5357-5367.

  https://doi.org/10.1523/JNEUROSCI.5017-09.2010

  PMID: 20392957

• Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.

  McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG

  Proc Natl Acad Sci U S A. 2010 Feb; 107(5): 2271-2276.

  https://doi.org/10.1073/pnas.0905568107

  PMID: 20133871

• Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

  Patel S, Kingsley PJ, Mackie K, Marnett LJ, Winder DG

  Neuropsychopharmacology. 2009 Dec; 34(13): 2699-2709.

  https://doi.org/10.1038/npp.2009.101

  PMID: 19675536

• The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants.

  Hill MN, Hillard CJ, Bambico FR, Patel S, Gorzalka BB, Gobbi G

  Trends Pharmacol Sci. 2009 Sep; 30(9): 484-493.

  https://doi.org/10.1016/j.tips.2009.06.006

  PMID: 19732971

• Role of endocannabinoid signaling in anxiety and depression.

  Patel S, Hillard CJ

  Curr Top Behav Neurosci. 2009; 1: 347-371.

  https://doi.org/10.1007/978-3-540-88955-7_14

  PMID: 21104391 ISSN: 1866-3370

• Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation.

  Patel S, Hillard CJ

  Eur J Neurosci. 2008 Jun; 27(11): 2821-2829.

  https://doi.org/10.1111/j.1460-9568.2008.06266.x

  PMID: 18588527

• Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus.

  Hill MN, Carrier EJ, Ho W-SV, Shi L, Patel S, Gorzalka BB, Hillard CJ

  Hippocampus. 2008; 18(2): 221-226.

  https://doi.org/10.1002/hipo.20386

  PMID: 18058925

• Ritualistic excoriation and blood-letting resulting in anemia in borderline personality disorder.

  Patel S, Benaknin J, Tsao C

  Gen Hosp Psychiatry. 2006 Nov; 28(6): 539-540.

  https://doi.org/10.1016/j.genhosppsych.2006.07.008

  PMID: 17088171 ISSN: 0163-8343

• Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling.

  Patel S, Hillard CJ

  J Pharmacol Exp Ther. 2006 Jul; 318(1): 304-311.

  https://doi.org/10.1124/jpet.106.101287

  PMID: 16569753 ISSN: 0022-3565

• Endocannabinoids in neuroimmunology and stress.

  Carrier EJ, Patel S, Hillard CJ

  Curr Drug Targets CNS Neurol Disord. 2005 Dec; 4(6): 657-665.

  https://doi.org/10.2174/156800705774933023

  PMID: 16375683 ISSN: 1568-007X

• U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance.

  Rademacher DJ, Patel S, Ho W-SV, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ

  Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6): H2694-H2701.

  https://doi.org/10.1152/ajpheart.00978.2004

  PMID: 15695564 ISSN: 0363-6135

• Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress.

  Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB

  Neuropsychopharmacology. 2005 Mar; 30(3): 508-515.

  https://doi.org/10.1038/sj.npp.1300601

  PMID: 15525997 ISSN: 0893-133X

• Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala.

  Patel S, Cravatt BF, Hillard CJ

  Neuropsychopharmacology. 2005 Mar; 30(3): 497-507.

  https://doi.org/10.1038/sj.npp.1300535

  PMID: 15280883 ISSN: 0893-133X

• The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity.

  Patel S, Carrier EJ, Ho W-SV, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ

  J Lipid Res. 2005 Feb; 46(2): 342-349.

  https://doi.org/10.1194/jlr.M400377-JLR200

  PMID: 15576840 ISSN: 0022-2275

• Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling.

  Patel S, Roelke CT, Rademacher DJ, Hillard CJ

  Eur J Neurosci. 2005 Feb; 21(4): 1057-1069.

  https://doi.org/10.1111/j.1460-9568.2005.03916.x

  PMID: 15787710 ISSN: 0953-816X

• Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis.

  Patel S, Roelke CT, Rademacher DJ, Cullinan WE, Hillard CJ

  Endocrinology. 2004 Dec; 145(12): 5431-5438.

  https://doi.org/10.1210/en.2004-0638

  PMID: 15331569 ISSN: 0013-7227

• Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression.

  Lu H, Patel S, Luo F, Li S-J, Hillard CJ, Ward BD, Hyde JS

  Magn Reson Med. 2004 Nov; 52(5): 1060-1068.

  https://doi.org/10.1002/mrm.20265

  PMID: 15508149 ISSN: 0740-3194

• Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line.

  Rademacher DJ, Kearn CS, Carrier EJ, Patel S, Delgado MA, Barkmeier A, Klick DE, Breese NM, Pfister SL, Nithipatikom K, Campbell WB, Hillard CJ

  J Neuroimmunol. 2004 Apr; 149(1-2): 130-141.

  https://doi.org/10.1016/j.jneuroim.2003.12.022

  PMID: 15020073 ISSN: 0165-5728

• Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition.

  Seagard JL, Dean C, Patel S, Rademacher DJ, Hopp FA, Schmeling WT, Hillard CJ

  Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3): H992-1000.

  https://doi.org/10.1152/ajpheart.00870.2003

  PMID: 14615281 ISSN: 0363-6135

• Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity.

  Patel S, Rademacher DJ, Hillard CJ

  J Pharmacol Exp Ther. 2003 Sep; 306(3): 880-888.

  https://doi.org/10.1124/jpet.103.054270

  PMID: 12808005 ISSN: 0022-3565

• The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase.

  Patel S, Wohlfeil ER, Rademacher DJ, Carrier EJ, Perry LJ, Kundu A, Falck JR, Nithipatikom K, Campbell WB, Hillard CJ

  Br J Pharmacol. 2003 Jul; 139(5): 1005-1013.

  https://doi.org/10.1038/sj.bjp.0705334

  PMID: 12839875 ISSN: 0007-1188

• Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs.

  Rademacher DJ, Patel S, Hopp FA, Dean C, Hillard CJ, Seagard JL

  Am J Physiol Heart Circ Physiol. 2003 May; 284(5): H1570-H1576.

  https://doi.org/10.1152/ajpheart.00772.2002

  PMID: 12521935 ISSN: 0363-6135

• Cannabinoid-induced Fos expression within A10 dopaminergic neurons.

  Patel S, Hillard CJ

  Brain Res. 2003 Feb; 963(1-2): 15-25.

  https://doi.org/10.1016/s0006-8993(02)03797-6

  PMID: 12560108 ISSN: 0006-8993

• The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat.

  Patel S, Gerrits R, Muthian S, Greene AS, Hillard CJ

  Neurosci Lett. 2002 Dec; 335(2): 95-98.

  https://doi.org/10.1016/s0304-3940(02)01170-9

  PMID: 12459507 ISSN: 0304-3940

• Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice.

  Patel S, Hillard CJ

  J Pharmacol Exp Ther. 2001 May; 297(2): 629-637.

  PMID: 11303052 ISSN: 0022-3565

• DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons.

  Scruggs JL, Patel S, Bubser M, Deutch AY

  J Neurosci. 2000 Dec; 20(23): 8846-8852.

  PMID: 11102493

• Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation

  Sachin Patel, Keenan Johnson, Danielle Adank, Luis E Rosas-Vidal

  Affiliations expand

  PMID: 36160815

  PMCID: PMC9489534

  DOI: 10.1016/j.ynstr.2022.100481

• 2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

  Amanda Morgan, Danielle Adank, Keenan Johnson, Emily Butler, Sachin Patel

  Affiliations expand

  PMID: 36125319

  DOI: 10.1111/acer.14949

• Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment

  Andrew Scheyer, Farhana Yasmin, Saptarnab Naskar, Sachin Patel

  Affiliations expand

  PMID: 36100658

  PMCID: PMC9700791 (available on 2024-01-01)

  DOI: 10.1038/s41386-022-01438-7

• The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure

  Veronika Kondev, Amanda Morgan, Mustafa Najeed, Nathan D Winters, Philip J Kingsley, Lawrence Marnett, Sachin Patel

  Affiliations expand

  PMID: 35961791

  DOI: 10.1016/j.biopsych.2022.05.012

• Alcohol and Cannabinoids

  Jane Metrik, Sachin Patel

  Affiliations expand

  PMID: 35821767

  PMCID: PMC9232221

  DOI: 10.35946/arcr.v42.1.10

• 2-Arachidonolglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice.

  Amanda Morgan, Danielle Adank, Keenan Johnson, Emily Butler, Sachin Patel

  Alcohol Clinc Exp Res. 2022 Nov;46(11):2010-2024.

  https://doi.org/10.1111/acer.14949 
  PMID: 36125319

• The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure

  Veronika Kondev, Amanda Morgan, Mustafa Najeed, Nathan D Winters, Philip J Kingsley, Lawrence Marnett, Sachin Patel

  Biol Psychiatry. 2022 Nov 1;92(9):739-749

  https://doi.org/10.1016/j.biopsych.2022.05.012

  PMID: 35961791

• Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation

  Sachin Patel, Keenan Johnson, Danielle Adank, Luis E Rosas-Vidal

  Neurobiol Stress. 2022 Sep 3;20:100481

  https://doi.org/10.1016/j.ynstr.2022.100481

  PMID: 36160815

  Books and Book Chapters

• Endocannabinoid signaling and stress resilience

  Hill MN, Patel S

  Stress Resilience: Molecular and Behavioral Aspects. 2019 Nov; 349-362.

  https://doi.org/10.1016/B978-0-12-813983-7.00022-7

  ISBN: 9780128139837

• Pharmacology of drugs of abuse

  Martin PR, Patel S

  Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Fourth Edition. 2016 Feb;

  ISBN: 9781451191004

• Pharmacology of drugs of abuse

  Martin PR, Patel S, Swift RM

  Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition. 2012 Oct; 641-688.

  ISBN: 9781608312702